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KMID : 0043319890120010022
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Archives of Pharmacal Research
1989 Volume.12 No. 1 p.22 ~ p.25
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Pharmacological Evaluation of the Glycosidated Phenylpropanoids Containing Fraction from Orobanche crenata
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El Shabrawy OA
Melek FR/Ibrahim M/Radwan AS
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Abstract
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Ethylacetate fraction from Orobanche crenata, contained two phenylpropanoid glycosides, exhibited some pharmacological properties. It was found to be non-toxic to rats in oral doses up to 500mg/100gm body weight. In large doses, it lowered the arterial blood pressure of anaesthetized rats, and produced significant analgesic effect in mice and diuretic effect in rats. It further showed smooth muscle relaxant and antispasmodic effects in the isolated rabbit intestine and guinea-pig ileum respectively.
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